Gene: [04q12/PDGFRA] platelet-derived growth factor receptor, alpha polypeptide;
FAG | [1]
Biochemical studies have revealed at least two PDGF receptor classes, which
are possibly specific to different isoforms of the platelet cytokine (A
type receptor for PDGF-AA and -AB isoforms and B receptor for PDGF-BB
isoform). The gene for this receptor beta-peptide is located in chromosome
5 (GEM:05q3/PDGFRB). The PDGFR-like gene is
mapped: GEM:08p2/PRLTS. [2] The PDGF per se is a heterodimer; its A and B peptides are encoded by different but evolutionary related genes, which are mapped in chromosomes 7 and 22 (see GEM:07p22/PDGFA and GEM:22q1/PDGFB)." |
EVO | Significant homology was demonstrated between PDGFR, KIT protooncogene (GEM:04q12/KIT) and macrophage growth factor (GEM:01p/CSF1)." |
REF | IDN,FUN "Bishayee &:
PNAS, 83, N18, 6756-6760, 1986 PRO,LOC "Disteche &: CCG, 51, (HGM10), 990, 1989 IDN,CLO,SEQ,EXP "Matsui T &: Science, 243, 800-804, 1989 LOC,MAP "Spritz RA &: Genomics, 22, 431-436, 1994 FAG,EVO "see GEM:05q3/PDGFRB |
SWI | SWISSPROT: P16234 |
KEY | onc, cyk, mem, recp |
CLA | coding, basic |
LOC | 04 q12 |
MIM | MIM: 173490 |
EZN | ENZYME: 2.7.1.112 |
Смотрите также:
