EC 3.5.4.9 5,10-METHENYLTETRAHYDROFOLATE 5-HYDROLASE (DECYCLIZING)

: methenyltetrahydrofolate cyclohydrolase

: 5,10-methenylTHF + H2O = 10-formylTHF

( EC 1.5.1.5 ), ( EC 3.5.4.9 ) ( EC 6.3.4.3 ) . CH2THF F10THF , F10THF THF HCOOH .

(In eucaryotes occurs as trifunctional enzyme also having methylenetetrahydrofolate dehydrogenase (NADP('+)) (EC 1.5.1.5) and formatetetrahydrofolate ligase (EC 6.3.4.3) ACTIVITY. In some procaryotes occurs as a bifunctional enzyme also having dehydrogenase (EC 1.5.1.5) activity or formiminotetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity)

GEM: $ 14q24/MTHFD ( ) MIM: 172460

:

  • .
  • ( ):
  • CHTHF+H2O=F10THF