EC 6.3.4.3  

FORMATE:TETRAHYDROFOLATE LIGASE (ADP-FORMING)

: formate-tetrahydrofolate ligase , formyltetrahydrofolate synthetase

: ATP + FORMATE + THF = ADP + ORTHOPHOSPHATE + 10-formylTHF

( EC 1.5.1.5 ), ( EC 3.5.4.9 ) ( EC 6.3.4.3 ) . CH2THF F10THF , F10THF THF HCOOH .

(In eucaryotes occurs as a trifunctional enzyme also having methyl enetetrahydrofolate dehydrogenase (EC 1.5.1.5) and methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) activity) GEM: $ 14q24/MTHFD ( ) MIM: 172460

:

  • .
  • ( ):
  • ATP+FORM+THF=ADP+Pi+F10THF