(NADPH)



EC 1.5.1.5 5,10-METHYLENETETRAHYDROFOLATE:NADP('+) OXIDOREDUCTASE

: methylenetetrahydrofolate dehydrogenase (NADP('+))

: 5,10-methyleneTHF + NADP(+) = 5,10-methenylTHF + NADPH + H(+)

( EC 1.5.1.5 ), ( EC 3.5.4.9 ) ( EC 6.3.4.3 ) . CH2THF F10THF , F10THF THF HCOOH .

(In eucaryotes occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formyltetrahydrofolate synthase (EC 6.3.4.3) activity. In some procaryotes occurs as bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9))

GEM: $ 14q24/MTHFD ( )

MIM: 172460

:

  • .
  • ( ):
  • CH2THF+NADP=CHTHF+NADPH