Gene: [02q3/INHA] inhibin, alpha; activin, alpha;


FUN

Alpha inhibin gene encodes one of the chains of inhibins - gonadal glycoprotein hormones - that inhibit the secretion of the hypophyseal follicle stimulating hormone (FSH). Beta polypeptide of FSH - follitropin beta - is mapped to Chr 11 (GEM:11p13/FSHB). For more details, see FAM:INH/00.0."

FAG

See FAM:INH/00.0.

MOP

[1] The glycosilated alpha peptide has MM 18kD, whereas the primarily processed peptide is 14.6kD (134 amino acid residues; the mature mRNA is 1.5kb). The primary translation product, preproinhibin, consists of 366 amino acid residues, of which 18 N-terminal residues form a signal peptide, and the following 214 residues form a propeptide (including the C-terminal dipeptide Arg-Arg, at which the propeptide proteolysis occurs). Thus the mature (nonglycosilated) alpha peptide contains 134 amino acid residues.
[2] A great variety of alpha inhibin-like peptides (alpha-ILP), 31, 52, and 92 amino acids in length, are found in the seminal fluid. They are possibly derivatives of the proinhibin processing.
[3] On the beta peptide structure, see GEM:07p1/INHBA."

REF

COM,PEP,EXP "Li CH &: PNAS, 82, N12, 4041-4044, 1985
PRO,SEQ,MOP "Mayo KE &: PNAS, 83, N16, 5849-5853, 1986
COM,PEP,EXP "Ramasharma, Li: PNAS, 84, N11, 3595-3598, 1987
PAT "Tanabe &: J Clin Endocrinol Metab, 57, 24-31, 1983
PRO,LOC,FAG "see GEM:02q1/INHBB

SWI

SWISSPROT: P05111

KEY

sex, horm

CLA

coding, basic

LOC

02 q33-34

MIM

MIM: 147380

Смотрите также:

  • Gene superfamily: inhibins (activins); (INHA INHBA INHBB INHBC)
  • Gene: [19p133/AMH] anti-Mullerian hormone (mullerian inhibiting factor); persistent Mullerian duct syndrome, type I (pseudohermaphroditism, male internal; MIM:261550);