Gene: [02q1/INHBB] inhibin, beta B; activin, beta B;


FUN

Beta-B inhibin gene encodes one of the chains of inhibins and activins - gonadal glycoprotein hormones - that regulate the secretion of the hypophyseal follicle stimulating hormone (FSH). Beta polypeptide of FSH - follitropin beta - is mapped to Chr 11 (GEM:11p13/FSHB). For more details, see FAM:INH/00.0."

MOP

[1] Inhibin beta peptides have MM 10.7 kD (94 amino acids) and have been shown to be unglycosilated. In SDS electrophoresis, the beta peptide is revealed at the 14-kD band, however this is thought to be a result of abnormal migration in such a gele.
[2] On the alpha peptide structure, see GEM:07p1/INHBA.
[3] Structure of inhibin as a whole is described in FAM:INH/00.0."

FAG

[1] Beta-A inhibin gene is assigned to Chr 2 (GEM:07p1/INHBA). Beta-C inhibin gene is mapped to Chr 12 (GEM:12q131/INHBC).
[2] See also FAM:INH/00.0."

REF

LOC,FAG "Barton DE &: Genomics, 5, 91-99, 1989
LOC,FAG,CAG,MOU "Barton DE &: CCG, 46, (HGM9), 578, 1987
COD,SEQ,FAG "Burger HG &: Endocrinology, 122, 1701-1702, 1988
COD,SEQ,FAG "Mason AJ &: BBRC, 135, 957-964, 1986
COD,SEQ,FAG "Mason AJ &: Nature, 318, 659-663, 1985
EXP "Meunier &: PNAS, 85, N1, 247-251, 1988
FUN,PEP,SEQ "Seidah NG &: FEBS Lett, 175, N2, 349-355, 1984
FUN,PEP,SEQ "Sheth &: FEBS Lett, 165, 11-15, 1984
COD,SEQ,FAG "Ulvsback M &: BBRC, 164, N3, 1310-1315, 1989

SWI

SWISSPROT: P09529

KEY

sex, horm

CLA

coding, basic

LOC

02 c-q13

MIM

MIM: 147390

Смотрите также:

  • Gene superfamily: inhibins (activins); (INHA INHBA INHBB INHBC)
  • Gene: [19p133/AMH] anti-Mullerian hormone (mullerian inhibiting factor); persistent Mullerian duct syndrome, type I (pseudohermaphroditism, male internal; MIM:261550);
  • Gene: [02q3/INHA] inhibin, alpha; activin, alpha;