Gene: [07q22/PLGAI1] plasminogen activator inhibitor, type I (endothelial); [PLANH1 PAI1 ]
GEN | The gene length is 12.3 kb. Exons: 9; introns: 8 (Strandberg-1988). |
FUN | The product of gene PLGAI1 inhibits both types of plasminogen activators, thus participating in fibrinolysis, ovulation, cell migration etc." |
MOP | The molecular product is a glycoprotein with MM 50 kD. |
FAG | [1] The gene PLGAI1 is included in a group of functionally
related genes. Their symbols are changed in the HUGEN Catalogue so that
most of them begin with 'PLG'. These genes are: PLG - plasmin (an active
product of plasminogen, GEM:06q2/PLG); PLI -
plasmin inhibitor or antiplasmin (GEM:17p1/PLI);
PLGL - plasminogen-like gene (GEM:02^/PLGL);
PLGAT - tissue plasminogen activator (GEM:08p1/PLGAT); PLGAU - urokinase plasminogen
activator (GEM:10q24/PLGAU); PLGAUR -
receptor for urokinase plasminogen activator (GEM:19q132/PLGAUR); PLGAI1 - endothelial inhibitor
of plasminogen activators (GEM:07q22/PLGAI1); PLGAI2 - placental inhibitor of
plasminogen activators (GEM:18q221/PLGAI2);
PLGAI2L1- PLGAI2-like 1 (GEM:00.0/PLGAI2L1); PLGAI2L2- PLGAI2-like 2
(GEM:00.0/PLGAI2L2); PLGAI3 - inhibitor of
plasminogen activators, type III (GEM:14q321/PCI); at least two other types of
inhibitors of activators have been typed by immunological methods; [2] The product of PLGAI1 is also a component of the superfamily of serine protease inhibitors (serpins)." |
REF | CLO,EXP,MEB "Alessi &:
Eur J Biochem, 175, 531-540, 1988 CLO,SEQ,EXP "Ginsburg D &: J Clin Invest, 78, 1673-1680, 1986 LOC,LIN,MOL "Klinger KW &: PNAS, 84, N23, 8548-8552, 1987 SEQ,GEN,MOP,EAG "Strandberg L &: Eur J Biochem, 176, 609-616, 1988 CLO,SEQ,EXP "Van Zonneveld AJ &: PNAS, 85, N15, 5525-5529, 1988 REV,SEQ,FAG,FUN,MEB "Wun T-C: CRC Crit Rev Biotech, 8, N2, 131-148, 1988 |
SWI | SWISSPROT: P05121 |
KEY | hem, clot, pep |
CLA | coding, basic |
LOC | 07 q22 |
MIM | MIM: 173360 |
SYN | PLANH1 PAI1 |
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