Gene: [16p112/ITGAM] integrin, alpha M (Mac-1a; CD11B; p170); complement component receptor 3, alpha (p170; antigen CD11B); antigen CD11B (macrophage antigen Mac-1-alpha subunit); [CR3A CD11B ]
MOP | Alpha subunit (heavy, MM 155-165 kD) is noncovalently associated with beta (light) subunit (GEM:21q223/ITGB2), which is the common one for all the three leukocyte adhesion proteins - antigen LFA-1 (GEM:16p123/ITGAL), protein p150,95 (GEM:16p121/ITGAX), and antigen CR3 (MAC-1, MO1). The precise function within CR3 is not known." |
EVO | Homology was found with alpha-peptides of platelet glycoprotein IIb (GEM:17q2132/ITGA2B) and receptors for fibronectin (GEM:12q1/ITGA5) and vitronectin (GEM:02q3/ITGAV). All the three genes belong to the integrin superfamily (see FAM:ITG/00.0)." |
FAG | See FAM:ITG/00.0. |
REF | SEQ,LOC "Arnaout MA &: PNAS, 85, N8, 2776-2780, 1988 LOC,PRO,FAG "Corbi &: J Exp Med, 167, (May), 1597-1607, 1988 PRO,SEQ,PEP,MOP,EVO "Hickstein DD &: PNAS, 86, N1, 257-261, 1989 FUN,EXP,MEB "Soligo &: Eur J Haematol, 42, 173-181, 1989 FUN,EXP,MEB "Wright &: PNAS, 85, N20, 7734-7738, 1988 |
SWI | SWISSPROT: P11215 |
KEY | imm, comp, recp, mem |
CLA | coding, basic |
LOC | 16 p11.2 |
MIM | MIM: 120980 |
SYN | CR3A CD11B |
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