Gene: [12q1/ITGA5] integrin, alpha 5 (alpha F; antigen CD49E); fibronectin receptor, alpha polypeptide; [VLA5A CD49E ]


FAG

[1] The gene for the beta subunit of fibronectin receptor is mapped in the short arm of chr 10 (GEM:10p112/ITGB1); in chr 19p, a FNRB-like sequence was found (GEM:19p1/ITGB1L).
[2] On the gene group that is functionally related with fibronectin, see GEM:02q34/FN1."

EVO

Homology was revealed between alpha peptides of platelet glycoprotein IIB (GEM:17q2132/ITGB3), fibronectin receptor (GEM:12q1/ITGA5), and vitronectin receptor (GEM:02q3/ITGAV); all the three genes belong to the integrin family."

REL

FAM:ITG/00.0

REF

PRO,SEQ,EXP "Argraves WS &: J Cell Biol, 105, 1183-1190, 1987
PRO,SEQ,EXP "Argraves WS &: JBC, 261, 12922-12924, 1986
LOC,MOL,PRO "Sosnoski DM &: J Clin Invest, 81, 1993-1998, 1988

SWI

SWISSPROT: P08648

KEY

mem, recp

CLA

coding, basic

LOC

12 q11-13

MIM

MIM: 135620

SYN

VLA5A CD49E

鸯铗痂蝈 蜞赕:

  • Gene: [17q2132/ITGA2B] integrin, alpha 2b (antigen CD41B); coagulation factor I receptor, alpha subunit; fibrinogen receptor on platelets, alpha subunit; glycoprotein IIb (platelet IIb/IIIa complex); thrombasthenia, Glanzmann-Naegeli type (
  • Gene: [16p112/ITGAM] integrin, alpha M (Mac-1a; CD11B; p170); complement component receptor 3, alpha (p170; antigen CD11B); antigen CD11B (macrophage antigen Mac-1-alpha subunit); [CR3A CD11B ]
  • Gene superfamily: integrins; (ITGA1 ITGA2 ITGA2B ITGA3 ITGA4 ITGA4L ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAW ITGAX ITGB1 ITGB1L ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8)
  • HUGEN-疱鲥矧铕 翳狃铐尻蜩磬