Gene: [05q33/CSF1R] colony stimulating factor 1 (macrophage-specific, CSF-M) receptor; McDonough feline sarcoma viral homolog; friend-murine leukemia virus integration site 2 homolog; anemia macrocytic, refractory (5q-minus syndrome, MIM:153550); [MCSFR FMS ]


The GDB indicates the regional location q33.3-34 [GDB:G00-120-600:LOC='05 q33.3-34'].


There are two other friend-murine leukemia virus integration site homologues (GEM:06p2/FIM1 and GEM:03q27/FIM3) and several fms-related genes (GEM:13q12/FLT1; GEM:08p12/FGFR1; GEM:13q12/FLT3; GEM:04q12/PDGFRA; GEM:04q12/KIT; GEM:05q33/CSF1R; GEM:05q3/PDGFRB; GEM:19p132/TYK2) in the genome. They are assigned to the src multigene family, which comprises also the protooncogene c-ros-1 (GEM:06q22/ROS1)."


[1] After the first description (van den Berghe-1974) of a case of refractory macrocytic anemia associated with deletion of a part of the chr 5 long arm, a similar chromosomal aberration was also revealed in a number of other hematological pathologies, including those with malignant progression. In most cases, the clinical picture and the progression of anemia in 5q-minus cyndrome are relatively mild, and in the absence of other chromosomal aberrations in addition to 5q-minus, the transformation into acute leukemia is very unfrequent.
[2] Since a gene for the ligand (CSF1) is located close to that for the receptor, and, moreover, genes for many other cytokines are located in the same region of 5q3, it is not clear, if the FMS/CSF1R rearrangements only cause the cell malignization in 5q-minus syndrome."


Several synonymous designations for this marker are encountered, which reflect the history of the locus research. Syndrome 5q-minus (refractory macrocytic anemia; RMA) is known since 1974. In 1980s, the protooncogene FMS was mapped to this region of chr 5q, and RMA began to be related to its rearrangements due to 5q3 deletions; this was also the case for a number of other myelodysplastic syndromes (both spontaneous and induced in the course of cytostatic therapy; MDS, ANLL). Almost simultaneously the fms oncogene was shown to represent the receptor for macrophage growth factor."


EXP,PAT "Bunn: Clin Haematol, 15, 1023-1035, 1986
EXP,PAT "Dubreuil &: Blood, 72, N3, 1081-1085, 1988
LOC,CYG,PAT "Groffen J &: CCG, 37, (HGM7), 484, 1984
LOC,CYG,PAT "Groffen J &: NAR, 11, 6331-6339, 1983
SEQ,EVO "Hampe A &: PNAS, 81, 85-89, 1984
LOC,CYG,PAT "Le Beau MM &: Science, 231, 984-987, 1986
LOC,CYG,PAT "Morgan &: New Engl J Med, 314, 1322, 1986
LOC,FAG "Nguyen &: CCG, 46, (HGM9), 670, 1987
EXP,PAT "Nienhuis AW &: Cell, 42, 421-428, 1985
LIN "Roberts WM &: Cell, 55, 655-661, 1988
PRO,LOC "Roussel MF &: J Virol, 48, 770-773, 1983
SEQ,EVO "Schrader &: PNAS, 83, N8, 2458-2462, 1986
EXP,PAT "Stuart, Mangan: Am J Med, 80, 503-507, 1986
LOC,CYG,PAT "Tinegate &: Brit J Haematol, 53, 103-110, 1983
LOC,EVO,FAG "Van Cong N &: Hum Genet, 81, N3, 257-263, 1989
EXP,PAT "van den Berghe H: Scand J Haematol, 36, (Suppl 45), 78-81, 1986
EXP,PAT "van den Berghe H &: Cancer Genet Cytogenet, 17, 189-255, 1985
LOC,CYG,PAT "van den Berghe H &: Nature, 251, 437-438, 1974
EXP,PAT "Verbeek JS &: Brit J Haematol, 61, 135-138, 1985a
EXP,PAT "Verbeek JS &: Mol Cell Biol, 5, 422-426, 1985b
GEN,POL "Xu DQ &: PNAS, 82, 2862-2865, 1985




cyk, hem, onc, recp, vir


coding, basic


05 q33.2-.3


MIM: 164770



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  • ген c-myc: дерегуляция экспрессии
  • Лимфома (сокращения)
  • C-kit Протоонкоген и фактор роста стволовых клеток
  • Gene: [05q31/CSF2] colony stimulating factor 2 (granulocyte-macrophage); [GMCSF ]
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  • Gene: [01p/CSF1] colony stimulating factor 1 (macrophage-specific, CSF-M); [MCSF ]
  • CSF1R Ген