Gene: [10^/PRKM8] protein kinase, mitogen-activated 8 (MAP kinase); stress-activated protein kinase 1; c-jun N-terminal kinase 1;


SUM

[1] The c-Jun kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family that stimulate the transcriptional activity of c-jun transcription factor (GEM:01p3/JUN) in response to growth factors, proinflammatory cytokines, and certain environmental stresses, such as short wavelength UV light and osmotic shock. On other MAP kinases and MAP kinase cascades see in: GEM:22q112/PRKM1; GEM:15q22/PRKMK1.
[2] In humans, the JNK family includes: JNK1 (GEM:10^/PRKM8), JNK2 (GEM:05q35/PRKM9) and JNK3 (GEM:21q21/PRKM10). The JNKs are activated by treatment of cells with the inflammatory cytokine IL1 (GEM:02q13/IL1A; GEM:02q13/IL1B) and are inactivated by MKP1 (GEM:05q34/DUSP1)."

REF

CLO,SEQ "Derijard B &: Science, 267, 682-685, 1995
CLO,SEQ "Derijard B &: Cell, 76, 1025-1037, 1994
CLO,SEQ "Gupta S &: EMBO J, 15, 2760-2770, 1996

SWI

SWISSPROT: P45983

KEY

pep, sign

CLA

coding, basic

LOC

10

MIM

MIM: 601158

EZN

ENZYME: 2.7.1.?

鸯铗痂蝈 蜞赕:

  • Gene: [00.0/PRKMK7] protein kinase, mitogen-activated, kinase 7; MAP kinase kinase 7 (MAPKK 7); JNK-activating kinase 2;