COUP-TF


脏牝铕 镱漶屐彘耱忄 COUP 镱溧怆 蝠囗耜痂秭棹 鲥腩泐 溧 沐眍 耔耱屐 腓镨漤钽 戾蜞犷腓珈. [ Tran P. et al., 1992 , Ladias J.A.A. et al., 1992 , Widom R.L. et al., 1992 , Carter M.E. et al., 1994 , Nakshatri H. et al., 1994 , Kristaki E. et al., 1994 ] 祛泱 猁螯 铗礤皴睇 麒耠 铖眍忭 礤汔蜩忭 疱泱蝾痤 蝠囗耜痂秭梃 铋 沭箫稃 沐眍.

COUP-TF 恹耱箫帼 痤腓 蝠囗耜痂秭桀眄 疱镳羼耦痤 , 蝾痨铉 嚓蜩忤痼邋 溴轳蜮桢 祉钽桴 溴痦 疱鲥矧铕钼.

碾 羿牝铕钼 桤 镱漶屐彘耱忄 COUP-TF ( ARP-1 Ear3/COUP- TF ), 蜞赕 镳桧噤脲驵 觌囫耋 溴痦 疱鲥矧铕钼 , 腓汔礓 礤 桤忮耱睇 [ Jiang G. et al., 1995 , Mangelsdorf D.J. et al., 1995a ]. 骂珈铈眍, 铐 耧铖钺睇 铌噻囹 疋铄 溴轳蜮桢 磬 蝠囗耜痂秭棹 礤玎忤耔祛 铗 腓汔礓钼.

软蝈疱耥, 黩 疱泱蝾痦 疣轭磬 溧 沐眍 耔耱屐 颂, 襦轵 疋琨忄龛 羿牝铕钼 镱漶屐彘耱忄 COUP-TF 镥疱牮帼蝰 襦轵囔 疋琨忄龛 羿牝铕钼 桤 漯筱桴 镱漶屐彘耱 觌囫襦 溴痦 疱鲥矧铕钼 ( RAR , RXR HNF-4 ). 亦, 疱泱蝾痦 疣轭磬 沐眍 囡罾I , 耩邃礤鲥镱麇黜铋 圉桦-CoA- 溴汨漯钽屙噻 , 蜞赕 觌弪铟眍泐 疱蜩眍-疋琨忄邈 徨腙 II  襦轵 疋琨忄龛 COUP-TF 镥疱牮帼蝰 襦轵囔 疋琨忄龛 疱鲥矧铕钼 疱蜩眍邂铋 觇耠铗 RAR RXR, 觐蝾瘥 耱桁箅桊簋 蝠囗耜痂秭棹 [ Tran P. et al., 1992 , Widom R.L. et al., 1992 , Carter M.E. et al., 1994 , Nakshatri H. et al., 1994 ]. 橡邃镱豚汔弪, 黩 镱溧怆屙桢 蝠囗耜痂秭梃 箨噻囗睇 沐眍 镱 怆龛屐 羿牝铕钼 COUP 钺篑腩怆屙 桴 觐黻箴屙鲨彘 桁 疱鲥矧铕囔 玎 襦轵 疋琨忄龛 磬 耐.

鸯铗痂蝈 蜞赕:

  • 蓐聆桤桀眄 疱镟疣鲨 眢觌孱蜩漕: 忖邃屙桢
  • 衔淌 牮: 襦轵 疋琨忄龛 溴痦 徨腙钼 钺豚耱 镳铎铗铕
  • 缅 涝: 疱泱蝾痦 疣轭: 踵眈屦
  • 倚劳咽腥现任屯叟 岳室涡: 延吓惺死蜒: 以 2. 难 酪翁捞 秩褪
  • 缅 囡铍栾铒痤蝈桧 麇腩忮赅 / 镳铎铗铕
  • 绣蜩眍邂 觇耠铗: 疱泱鲨 耧疱耨梃 沐磬 涝
  • 缅睇 腓镨漤钽 戾蜞犷腓珈: 绣泱鲨 礤汔蜩忭
  • 缅 囡铍栾铒痤蝈桧 麇腩忮赅 / 礤汔蜩忭 疱泱蝾痦 屐屙